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Dyclonine hydrochloride: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Dyclonine hydrochloride - General Information

Dyclonine hydrochloride is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray.

 

Pharmacology of Dyclonine hydrochloride

Dyclonine hydrochloride is an oral anasthetic. If substantial quantities of local anesthetics are absorbed through the mucosa, actions on the central nervous system (CNS) may cause CNS stimulation and/or CNS depression. Actions on the cardiovascular system may cause depression of cardiac conduction and excitability and, with some of these agents, peripheral vasodilation.

 

Additional information about Dyclonine hydrochloride

Dyclonine hydrochloride Indication

Used to provide topical anesthesia of accessible mucous membranes prior to examination, endoscopy or instrumentation, or other procedures involving the esophagus, larynx, mouth, pharynx or throat, respiratory tract or trachea, urinary tract, or vagina. Also used to suppress the gag reflex and/or other laryngeal and esophageal reflexes to facilitate dental examination or procedures (including oral surgery), endoscopy, or intubation. Also used for relief of canker sores, cold sores or fever blister.

Mechanism Of Action
Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
Generic Name
Dyclonine
Drug Category
Anesthetics, Mucosal-Local
Drug Type
Small Molecule; Approved
Other Brand Names containing Dyclonine
Diclonia; Diclonina; Diclonina [INN-Spanish]; Dyclocaine; Dyclocainum; Dyclone; Dyclonin; Dyclonine HCL; Dyclonine hydrochloride; Dycloninum [INN-Latin]; Dyclothane; Tanaclone;
Absorption
Readily absorbed through mucous membranes into the systemic circulation. The rate of absorption is influenced by the vascularity or rate of blood flow at the site of application, the total dosage (concentration and volume) administered, and the duration of exposure. Absorption from mucous membranes of the throat or respiratory tract may be especially rapid.
Toxicity (Overdose)
Symptoms of overdose include cardiovascular system depression, CNS toxicity, and methemoglobinemia.
Half Life
Approximately 30 to 60 minutes.
Dosage Forms of Dyclonine hydrochloride
Lozenge Oral
Chemical IUPAC Name
1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one
Chemical Formula
C18H27NO2
Organisms Affected
Humans and other mammals